![]() The simplest way to restore anything to your computer is to select your chosen category, then click the Transfer button and choose the Sync option. Mac users get the best deal here - version 2 now supports videos, podcasts, ringtones, books and photos too PC users must make do with audio and video content. Once done, it's just a case of plugging in your iPod – after a short pause a list of all your music will be displayed, with options to view other content too. Download and launch the program without plugging in your iPod – the first thing it'll do is check to see if auto-sync is enabled in iTunes if it is, you'll be warned about switching it off before you go any further. iRip aims – like most Little App Factory products – to make this process as simple as possible. This is a problem third-party vendors have fallen over themselves to provide a solution for. First, iTunes is automatically set to synchronise your iPod with your computer's contents, which means if you fire it up expecting to transfer your iPod's content back you'll not only be disappointed, you may even end up wiping the content from your iPod! The regulation by IRIP on transporter activities likely occurs at a post-transcriptional level, and future studies are needed to characterize the exact mechanism.Getting music from your computer to your iPod, iPhone and iPad is easy thanks to iTunes, but the reverse isn’t always true: if you want to transfer your media collection back from your iPod to a new computer or your existing computer as part of a data recovery exercise, it’s less straightforward. Importantly, we provide in vivo evidence for such modulation that may cause an alteration in drug disposition. In conclusion, IRIP negatively modulates the function of OCT1 and MATE1 in cells. In addition, we observed that the expression of IRIP was approximately half (P < 0.01) in ob/ob mice when compared to their lean littermates, with significant increases in hepatic Oct1 protein expression and metformin accumulation. By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01). IRIP overexpression decreased the membrane localization of transporter proteins without any changes in transcript levels in cells. In contrast, knockdown of IRIP by small hairpin RNA (shRNA) increased the transporter activities in vitro. In the uptake studies in the human embryonic kidney 293 cells overexpressing IRIP with and without OCT1 or MATE1, IRIP overexpression was found to significantly inhibit the uptake of 1-methyl-4-phenylpyridinium mediated by OCT1 or MATE1. The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug for diabetes and other obesity-related syndromes. The recently identified ischemia/reperfusion-inducible protein (IRIP) has been reported to negatively modulate the activities of several transporters in cell culture systems.
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